Storing and Reconstituting Lyophilised Research Peptides

Lyophilised (freeze-dried) peptides are supplied as a dry powder for stability and ease of transport. How they are stored and handled in the laboratory has a direct effect on their integrity over time.

Storage of the dry powder

Before reconstitution, most lyophilised research peptides are best kept cold and dry. Short periods at ambient temperature during shipping are generally tolerated, but for storage the dry vial should be refrigerated, or frozen for longer periods, and protected from light and moisture.

Reconstitution

For laboratory work, lyophilised peptides are typically reconstituted with a suitable solvent such as bacteriostatic water. Add solvent gently down the side of the vial rather than directly onto the powder, and allow the material to dissolve without vigorous shaking, which can stress the peptide.

After reconstitution

Once in solution, peptides are less stable than in their dry form and should be kept refrigerated and used within the timeframe appropriate to your protocol. Aliquoting can reduce freeze-thaw cycles, each of which can contribute to degradation.

General good practice

Label vials clearly with compound, lot number and reconstitution date; minimise temperature fluctuations; and keep handling to a minimum. These simple habits help preserve material quality across a research programme.

For laboratory research use only. Not for human or veterinary use.